Discoid lupus symptoms, diagnosis, treatments and causes. While the face, trunk and extremities are frequently affected, eyelid involvement is uncommon and often presents as a diagnostic problem. Kondisi pasien mungkin berfluktuasi dan berakibat fatal jika. Lespecific skin manifestations can be further subdivided into acute cle acle, subacute cle scle and chronic cle ccle where classic discoid le dle. At one end of the range is systemic lupus erythematosus, which can damage internal organs, whilst right at the other end of the range is discoid lupus. It is characterised by persistent scaly, disklike plaques on scalp, face and ears that may cause pigmentary changes, scarring and hair loss. Classic dle lesions begin as redpurple macules, papules or small plaques and rapidly develop a. The clinical course is variable, with a broad spectrum of organ manifestations. Discoid lupus erythematosus cutaneous lupus erythematosus. Symptoms vary between people and may be mild to severe. Laporan kasus cutaneus discoid lupus erythematosus. It has a characteristic clinical appearance consisting of red, scaly plaques with resulting pigmentary changes and scars.
Berbeda dengan dle yang hanya akan menunjukkan manifestasi pada kulit, sle merupakan tipe le yang juga dapat menunjukkan manifestasi pada organ tertentu selain pada kulit. Only about 10% of all patients with dle will go on to develop the multiorgan disease sle. It typically causes a loss of color in the hairless, moist part of the nose. The disease called discoid lupus erythematosus only affects the skin, although similar discoid skin lesions can occur in the serious disease called systemic lupus erythematosus sle. Bila keadaan penyakit serius, seperti nefritis lupus akut, sistem saraf lupus, pneumonia lupus, peradangan hemolitik atau leukosit rendah, dokter. The term lupus erythematosus is applied to a range of related disorders. Lupus is a widespread and chronic lifelong autoimmune disease that, for unknown reasons, causes the immune system to attack the bodys own tissue and organs, including the joints, kidneys, heart, lungs, brain, blood, or skin. Dinamakan lupus sistemik dikarenakan terjadi pada berbagai organ, terutama sendi, ginjal, dan kulit. Lupus erythematosus le terdiri dari systemic lupus erythematosus sle dan discoid lupus erythematosus dle. Classic dle lesions begin as redpurple macules, papules or.
It is classified as either localised, affecting skin above the neck only, or generalised, affecting above and below the neck. Discoid lupus penyebab, gejala, dan pengobatan honestdocs. Discoid lupus erythematosus an overview sciencedirect topics. Gejala utamanya adalah inflamasi kronis pada organorgan. Discoid lupus erythematosus dle is a skin condition of dogs. At one end of the range is systemic lupus erythematosus, which can damage internal organs, whilst right at the other end of the range is discoid lupus erythematosus, which is confined to the skin and does not cause general ill health. Aug 21, 2018 lupus erythematosus is a polygenic autoimmune disease linked to various hla subtypes, immune signaling, and environmental factors, which ultimately leads to autoantibody production and tcell dysfunction. It is a chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas. Discoid lupus erythematosus dle is a common autoimmune skin condition in dogs. Discoid lupus erythematosus jarang ditemukan pada anakanak. Chronic cutaneous le most commonly is manifest by the discoid. Typically, discoid lupus is characterized by erythematous macules, papules, and plaques with telangiectases, scale, and follicular plugs, which results in a scaring process with atrophy.
Jun 24, 2014 ladies, discoid lupus erythematosus pada umumnya dapat menyerang siapa saja baik lakilaki maupun perempuan, namun, yang paling sering adalah pada perempuan usia muda. Penyakit ini berhubungan dengan deposisi autoantibodi dan kompleks imun, sehingga mengakibatan kerusakan jaringan. Sistemik lupus erythematosus adalah suatu penyakit kulit menahun yang ditandai dengan peradangan dan pembetukan jaringan parut yang terjadi pada wajah, telinga, kulit kepala dan kandung pada bagian tubuh lainnya. Manifestasi klinis cdle bervariasi dan melibatkan banyak organ baik beberapa organ berbeda maupun berkaitan selama periode penyakit berlangsung. Cutaneus discoid lupus erythematosus cdle merupakan penyakit autoimun sistemik dengan penyebab multifaktor, yang ditandai keterlibatan beberapa organ dan sistem oleh karena kelainan imunologi. At one end of the range is systemic lupus erythematosus, which can. Aug 30, 2017 discoid lupus discoid lupus erythematosus is a chronic autoimmune disease affecting the skin. Kriteria diagnosis sle systemic lupus erythematosus.
Discoid lupus erythematosus dle, also known as cutaneous lupus erythematosus, is an autoimmune disease that affects the skin, in which the bodys own immune system is activated to attack the body. The diagnosis and treatment of systemic lupus erythematosus. Ldle, characterized by welldefined macular or papular erythematous lesions with firm scales adher. A case of discoid lupus erythematosus because of palbociclib. Discoid lupus erythematosus dle lesions develop in up to 25% of sle patients.
Discoid lupus erythematosus is the most common type of chronic cutaneous lupus ccle, an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. The term lupus erythematosus is applied to a range of. Discoid lupus erythematosus dle is the most common form of cutaneous lupus erythematosus. Abstrak penyakit systemic lupus erythematosus sle adalah salah satu penyakit yang terkait dengan sistem imun. Risk of systemic lupus erythematosus is approximately 5%. It is caused or triggered by exposure to ultraviolet radiation, cold and drugs and develops gradually. Pdf cutaneous lupus erythematosus issues in diagnosis. Pdf discoid lupus erythematosus dle is the most common form of chronic cutaneous lupus erythematosus. In discoid lupus erythematosus, the alopecic area shows active inflammation with erythema, edema, scaling, and follicular plugging, as well as atrophy with variable degrees of telangiectasia and dyspigmentation. However, the exact etiology of discoid lupus erythematosus dle is not well understood. Dogs with dle develop crusting and scabbing of the skin, most commonly starting around the nose, as well as a loss of skin pigmentation in the affected area. Indeed, it is the diversity of presentation, accumulation of manifestations over time, and undulating disease course that challenge the most astute of clinicians. Salah satu penyakit autoimun yang banyak dikenal dan ditemui di masyarakat adalah penyakit lupus atau systemic lupus erythematosus sle. Discoid lupus erythematosus definition of discoid lupus.
Discoid lupus tidak memiliki satu penyebab yang sangat jelas. Oct 29, 2017 discoid lupus erythematosus mainly affects skin that is exposed to sunlight and doesnt typically affect vital internal organs. Discoid lupus erythematosus is a chronic dermatological disease that can lead to scarring, hair loss, and hyperpigmentation changes in skin if it. Pdf to determine the demographic data, clinical pattern and therapeutic outcome in patients with discoid lupus erythematosus dle. Discoid lupus erythematosus dle is consistently reported as the most common subtype, and this may be because as a chronic disorder, it is. It is confined to the skin and does not cause any systemic symptoms. Lupus, technically known as systemic lupus erythematosus sle, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. Feb 22, 2016 discoid lupus erythematosus dle is a chronic photosensitive skin eruption which can be either localised or widespread. Discoid lupus erythematosus of the eyelids harvey siy uy, md introduction. Discoid lupus erythematosus dle is the most common form of chronic cutaneous lupus erythematosis according to the classification proposed by gilliam 1, 2. Ldle, characterized by well defined macular or papular erythematous lesions with firm scales adher. Dermatology unit, department of mentals and physical health and preventive medicine, university of campania luigi vanvitelli, naples, italy.
Discoid cutaneous lupus erythematosus vca animal hospital. Banyak faktor yang memengaruhi terjadinya kasus sle di indonesia, antara lain belum terpenuhinya kebutuhan pasien dan keluarganya tentang informasi, pendidikan, dan. Lupus erythematosus is an auto immune connective tissue disease which consists of discoid lupus erythematosus dle and systemic lupus erythematosus sle. Laporan kasus cutaneus discoid lupus erythematosus yunara. Penyakit lupus atau sle ini memiliki gejala dan tampilan klinis yang beragam sehingga dalam menegakan diagnosis lupus harus memenuhi kriteriakriteria tertentu. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. Discoid lupus erythematosus dle is a disfiguring autoimmune skin disease and the most common form of chronic cutaneous lupus erythematosus. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Females are more often affected, and the disease is more common in african american women.
Discoid lupus erythematosus dle is the most common form of chronic cutaneous lupus erythematosus. It gets its name from the coinshaped lesions it produces. Discoid lupus erythematosus dle is a chronic autoimmune skin condition characterized by erythematous lesions with scaly and crusty appearances. Jenis penyakit ini menyerang berbagai jaringan seperti, sendi, kulit, otak, paruparu, ginjal, dan pembuluh darah. Discoid lupus discoid lupus erythematosus is a chronic autoimmune disease affecting the skin. Lupus eritematosus sistemik systemic lupus erythematosussle lupus ini terjadi secara menyeluruh sistemik pada tubuh penderita dan merupakan jenis lupus yang paling sering terjadi. Discoid lupus erythematosus dle is a chronic inflammatory condition of the skin. Discoid lupus erythematosus dle is a benign, autoimmune disorder of the skin. Dle can cause permanent scarring if treatment is inadequate. With rare exception, the unifying laboratory abnormality is. Discoid lupus erythematosus in dogs symptoms, causes. Jan 21, 2020 lupus diskoid adalah jenis lupus yang paling umum dari kondisi pada penyakit autoimun, yang berarti bahwa sistem kekebalan tubuh secara keliru mengidentifikasi jaringannya sendiri sebagai benda asing dan meningkatkan serangan. Discoid lupus erythematosus british association of. Discoid lupus erthematosus, adalah jenis lupus yang menyerang jaringan kulit, sehingga menyebabkan ruamruam.
It is relatively easy to diagnose and is also treatable. Lupus eritematosus diskoid adalah penyakit kulit yang menyebabkan skuama dan lesi kemerahan pada kulit yang diperparah oleh paparan sinar matahari. Jun 19, 2015 systemic lupus erythematosus sle is an autoimmune disease with a prevalence of 36. Chronic cutaneous discoid lupus erythematosus ccdle or discoid lupus eryhthematosus dle is a rare chronic autoimmune dermatosis and the most common clinical variant of the lupus erythematosus le. Systemic lupus erthematosus sle, merupakan jenis lupus yang paling sering terjadi. Pathogenesis 20 and clinical features 1 introduction systemic lupus erythematosus sle is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues. Discoid lupus erythematosus biasanya dapat terbawa oleh gen, sehingga jika terdapat keluarga yang terkena penyakit. Early diagnosis and treatment of discoid lupus erythematosus.
Discoid lupus erythematosus is an uncommon skin rash, usually made worse by exposure to sunlight. Cutaneus discoid lupus erythematosus cdle merupakan penyakit autoimun sistemik dengan penyebab multifaktor, yang ditandai. Discoid lupus erythematosus symptoms, diagnosis and. Ini adalah obat yang sangat penting untuk mengobati lupus eritematosus sistemik, yang dapat mengurangi peradangan, memperbaiki kelelahan, dan penggunaan luarnya dapat membantu menyembuhkan ruam.
Dle discoid lupus collie nose what is discoid lupus. Discoid lupus erythematosus british association of dermatologists. Penyakit sle masih tergolong penyakit yang awam di indonesia. Laporan kasus cutaneus discoid lupus erythematosus cutaneus discoid lupus erythematosus cdle merupakan penyakit autoimun sistemik dengan penyebab multifaktor, yang ditandai keterlibatan beberapa organ dan sistem oleh karena kelainan imunologi. Discoid lupus erythematosus dle is a form of lupus erythematosus marked by chronic skin eruptions. Pdf cutaneous lupus erythematosus le may present in a variety of clinical forms. Dle lesions begin as welldemarcated erythematous macules or papules with a scaly surface, and frequently evolve into larger coinshaped plaques. Discoid lupus erythematosus symptoms, diagnosis and treatment. Tempat yang paling utama untuk lesi led biasanya terjadi pada muka, leher, dahi, telinga, dada, bahu dan punggung atas. Lupus erythematosus le is a group of diverse, persistent inflammatory autoimmune diseases and often affects the skin.
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